Bogenschutz, M.P., Forcehimes, A.A., Pommy, J.M., Wilcox, C.E., Barbosa, P.C.R., Strassman, R.J. (2015) Journal of Psychopharmacology , 29(3) , 289-299
Zusammenfassung
Single-group proof-of-concept study (N=10) evaluating psilocybin-assisted therapy (one or two dosing sessions integrated with Motivational Enhancement Therapy) in DSM-IV alcohol-dependent adults. Significant post-psilocybin increases in abstinent days and reductions in heavy drinking were maintained through 36-week follow-up. Greater acute subjective intensity during the first psilocybin session predicted larger subsequent reductions in alcohol use, craving, and improved abstinence self-efficacy, suggesting experiential (possibly mystical-type) factors mediate therapeutic change. No serious treatment-related adverse events occurred. Findings support controlled randomized trials to investigate efficacy, psychological and neurobiological mechanisms, and optimal integration strategies for alcohol use disorder.