de-DEen-US
Skip to main content
Resources for psychedelic research and consciousness expansion (LSD derivatives)

Scientific Research

Significance and Potential of Psychedelics in Science

Single-dose synthetic psilocybin with psychotherapy for treatment-resistant bipolar II depression: open-label trial
Single-dose synthetic psilocybin with psychotherapy for treatment-resistant bipolar II depression: open-label trial

Aaronson, S.T., van der Vaart, A., Miller, T., LaPratt, J., Swartz, K., Shoultz, A., Lauterbach, M., Sackeim, H.A., Suppes, T. (2024) JAMA Psychiatry , 81(6) , 555-562

Abstract

Open-label, nonrandomized trial of a single 25 mg dose of synthetic psilocybin with structured psychotherapy in adults with treatment-resistant bipolar II depression. Depressive symptoms improved at 3 and 12 weeks, with no significant increase in mania or suicidality, supporting further controlled studies in this population.

Keywords

psilocybinbipolar IIdepressionopen-label trialpsychotherapytreatment-resistantsafetyclinical outcomes
Clinical Research
View Article