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Brain scan showing neural activity during psychedelic experience

The Science of Psychedelics: How They Affect Your Brain

Yasmin

Yasmin

Yoga- & Breath Work Trainerin

Published on

June 1, 2025

Updated on

June 1, 2025

min read

15 min

How Psychedelics Change Your Brain

Scientists are learning more about how psychedelics work in the brain. This is helping us understand how they can be used to help people.

The Serotonin Connection

Most psychedelics work with a chemical in your brain called serotonin. They connect with a specific part of your brain cells called the 5-HT2A receptor. This can change how you see, think, and feel.

A More Connected Brain

Quieting the "Ego" Network

There's a part of your brain called the Default Mode Network (DMN). It's like your brain's "autopilot" and is active when you're thinking about yourself. Psychedelics quiet down this network. This can lead to a feeling of "ego death" and may help with depression and anxiety.

A More Flexible Brain

Brain scans show that psychedelics help different parts of your brain talk to each other more. This makes your brain more flexible and open to new ideas.

How Psychedelics Can Help

A More "Plastic" Brain

Psychedelics can help your brain grow new connections and learn new things. This is called neuroplasticity.

Healing from Trauma

Psychedelics may help you process difficult memories and emotions. They can also help you feel more in control of your feelings.

Reducing Inflammation

Some research shows that psychedelics can reduce inflammation in the brain. This could be good for your brain's health in the long run.

What the Research Says

Depression and Anxiety

Studies show that psychedelics can quickly reduce symptoms of depression and anxiety. These benefits can last for months.

PTSD

Psychedelics may help people with PTSD by reducing their symptoms and helping them feel more in control.

Addiction

Psychedelics may help people break free from addiction by changing their thought patterns and increasing their motivation to change.

Set and Setting Still Matter

Science shows that your mindset ("set") and your environment ("setting") are very important for a good experience.

Safety First

Psychedelics are generally safe for the body, but they are not for everyone. People with certain mental health conditions should not use them. It's important to have medical support.

What's Next?

Scientists are still learning about the best ways to use psychedelics. They are studying things like the right dose and how to combine them with therapy.

We're experiencing a renaissance in psychedelic science. These substances reveal fundamental truths about consciousness and offer new hope for treating mental illness. - Roman, Limitless Retreats Team

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About the Author

Yasmin

Yasmin

Yoga- & Breath Work Trainerin

Yasmin bringt acht Jahre Erfahrung in Yoga-, Atem- und Meditationspraktiken mit. Ihre einfühlsamen Sitzungen bereiten die Teilnehmer ganzheitlich auf ihre psychedelische Reise vor und vermitteln wertvolle Techniken, um auch herausfordernde Momente zu meistern und die gewonnenen Erkenntnisse durch achtsame Körperwahrnehmung nachhaltig zu integrieren.

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