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Scientific Research

Significance and Potential of Psychedelics in Science

The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs
The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs

Carhart-Harris, R.L., Leech, R., Hellyer, P.J., Shanahan, M., Feilding, A., Tagliazucchi, E., Chialvo, D.R., Nutt, D. (2014) Frontiers in Human Neuroscience

Abstract

This paper introduces the Entropic Brain Hypothesis, proposing that the quality of consciousness is indexed by the entropy of brain activity. Psychedelics increase brain entropy, temporarily shifting consciousness to a more flexible, less constrained state — explaining both the therapeutic potential and the phenomenology of psychedelic experiences.

Keywords

entropic brainconsciousnessentropypsychedelicsneuroimagingdefault mode network
Neuroscience