Scientific Research

Abstract

This paper reviews safety considerations for human research with classical hallucinogens (psychedelics). Although these compounds are relatively safe physiologically and are not considered drugs of dependence, their administration involves unique psychological risks, including acute distress ('bad trips') and rare prolonged psychoses. The authors outline safeguards to minimize risk: careful screening (including exclusion of volunteers with personal or family history of psychotic or severe psychiatric disorders), thorough preparation, a safe physical environment, and continuous interpersonal support from trained monitors. Follow-up should probe for hallucinogen persisting perception disorder. When conducted with these guidelines, persisting adverse reactions are rare; incautious research may jeopardize participant safety and future work. Carefully conducted studies can inform treatment of psychiatric disorders and advance basic science.