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Significance and Potential of Psychedelics in Science

Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo
Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo

Shao, L.-X., Liao, C., Gregg, I., Davoudian, P.A., Savalia, N.K., Delagarza, K., Kwan, A.C. (2021) Neuron , 109(16) , 2535-2544.e4

Abstract

Demonstrates that a single dose of psilocybin leads to approximately 10% increase in dendritic spine size and density in the mouse frontal cortex within 24 hours, with structural effects persisting for at least one month.

Keywords

psilocybindendritic spinesneuroplasticityfrontal cortexneuroscience
Neuroscience
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