Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo
Shao, L.-X., Liao, C., Gregg, I., Davoudian, P.A., Savalia, N.K., Delagarza, K., Kwan, A.C. (2021) Neuron , 109(16) , 2535-2544.e4
Abstract
Demonstrates that a single dose of psilocybin leads to approximately 10% increase in dendritic spine size and density in the mouse frontal cortex within 24 hours, with structural effects persisting for at least one month.
Keywords
psilocybindendritic spinesneuroplasticityfrontal cortexneuroscience
Neuroscience