Trial of Psilocybin versus Escitalopram for Depression
Carhart-Harris, R., Giribaldi, B., Watts, R., Baker-Jones, M., Murphy-Beiner, A., Murphy, R., Martell, J., Blemings, A., Erritzoe, D., Nutt, D.J. (2021) New England Journal of Medicine , 384(15) , 1402-1411
Abstract
Phase 2 double-blind randomized controlled trial comparing psilocybin with escitalopram for moderate-to-severe major depressive disorder. While the primary outcome showed no significant difference, secondary outcomes favored psilocybin over the 6-week period.
Keywords
psilocybinescitalopramdepressionSSRI comparisonrandomized controlled trial
Clinical Research